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Sleep plays a critical role in regulating lethargy levels by restoring neurological, hormonal, and metabolic balance. During adequate sleep, the brain clears metabolic waste, stabilizes neurotransmitters, and regulates cortisol, all of which support daytime alertness. Chronic sleep deprivation disrupts these processes, leading to persistent fatigue, reduced concentration, and slowed reaction time. Poor sleep quality also impairs immune function, increasing perceived exhaustion during illness. While medications and supply topics such as cephalexin wholesale relate to healthcare operations, they do not offset the physiological need for sleep. Consistent sleep duration, quality, and circadian alignment remain foundational determinants of energy and reduced lethargy.